Rampaging through New York is an uncontrolled rage is the Lizard! Once the genetic scientist and mutation expert D. Curt Connors, he was transformed when he attempted to re-grow his lost arm by infusing his own DNA with that of a lizard. Now the Lizard and the Man-Spider are on the loose in New York City, and monster mayhem rages in the streets! Using his incredible strength and animal-like intelligence, the transformed Dr. Connors has only one chance--that Spider-Man will reverse the mutagenic process.