Mutating out of control due to an explosion at Dr. Curt Connors' laboratory, the man who was once Peter Parker and Spider-Man has now become the monstrous Man-Spider! More arachnid now than man, the Man-Spider acts on instinct alone--and his fading memories first take him to his place of work, the Daily Bugle! But New Yorkers do not react well to a 7-foot tall Man-Spider crawling through their city! Attacked by normal citizens and staked by Kraven the Hunter, the creature who was once Spider-Man escapes and moves on, instinctively searching for the one man that can cure him--the Lizard!